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Notably, we previously demonstrated that HITI-mediated GFP gene knock-in efficiency, as measured by digital PCR, closely correlates with the percentage of GFP-positive liver cells detected by flow cytometer 13

* Correspondence: Xu Zhai, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

10.1016/j.cmet.2024.01.011 62 RowlandsJ.HengJ.NewsholmeP.CarlessiR

According to the FDA prescribing information, this active ingredient (empagliflozin) causes the kidneys to excrete 50-90 grams of extra glucose daily through urine, creating a caloric deficit of 200-300 calories

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