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Description
They block the reabsorption of glucose and sodium in the proximal tubule, causing glucosuria and natriuresis (see diagram below)
This delayed gastric emptying is responsible for semaglutide's appetite-suppressing effects and improved blood sugar control
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Lancet 2011;377:658-66
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Acknowledgements The authors thank Edson Fernandes de Assis for performing the cytokine assays with the multiplex platform and the Fiocruz network of technological platforms and the confocal platform from the Oswaldo Cruz Foundation, Fiocruz, Rio de JaneiroManguinhos Mar campus
