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In addition, GLP-1 and its own receptors are synthesized in the same brain regions, strongly supporting the actions of this peptide on the CNS
References Chao, A
The biggest risk is diabetic ketoacidosis, especially if insulin doses are reduced too much
People with higher starting BMI Individuals with BMI above 40 often see faster absolute weight loss in the early phases, simply because a higher body weight means a larger caloric expenditure even at rest, and the same percentage reduction in food intake creates a larger absolute caloric deficit
Optimal dose of tirzepatide for type 2 diabetes mellitus: A meta-analysis and trial sequential analysis
