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160,161 For example, HM15211, a triple agonist developed by Hanmi Pharmaceutical in South Korea that activates GLP-1R, GIPR and GCGR has entered early clinical trials for the treatment of obesity and non-alcoholic steatohepatitis (NASH)

Liraglutide has anti-inflammatory effects on endothelial cells by decreasing activation of NF-kB, inhibiting TNF-alpha, and increasing nitric oxide production (28)

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Neuron , 109 (3), 461-472

Phase 3 TRIUMPH-4 (topline) In Lillys topline summary, the most common adverse events included nausea, diarrhoea, constipation and vomiting (typical of incretin-based therapies)