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Description
The success of these agents in preclinical models and clinical trials suggests a promising future for multiagonists in the treatment of metabolic diseases, with the most recent glucose-dependent insulinotropic peptide receptor:glucagon-like peptide 1 receptor:glucagon receptor (GIPR:GLP-1R:GCGR) triagonists rivaling the efficacy of bariatric surgery
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Volume-sensitive synaptic input to neurons in guinea pig inferior mesenteric ganglion
Side effects, the need for regular monitoring, and potential restrictions (like avoiding them while breastfeeding, for now) mean theyre not right for everyone
Other GLP-1 and glucagon co-agonists in early phase clinical trials as treatments for obesity include AZD9550 and LY3305677 (NCT05623839)
Typically, these medications are administered once a week through a subcutaneous injection
