if magic glp 1 GLP-1 medications are a tool — not magic., They can help reduce appetite and slow digestion, making it easier to eat less., But they don’t replace healthy habits., you’re using a GLP-1 medication, GLP-1 receptor agonists | How

GLP1-R agonists have been shown to provide anti-inflammatory and endothelial protective benefits through the activation of peroxisome proliferator-activated receptor (PPAR)

Abstract Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are one of the most effective treatments for obesity

ALT-801 (denoted as Compound 17) has also been shown to reduce blood glucose in the diabetic db/db mouse model at least as well as an equivalent dose of semaglutide 20 , suggesting that the glucoregulatory effects of the GLP-1R activation by ALT-801 were not disrupted by simultaneous agonism of the GCGR

GLP-1: glucagon-like peptide-1

A study that would be very challenging to run (controlled fixed diet - with and without GLP1)

application requires sufficient dose to occupy carrier protein sites in plasma and simultaneously exposes non-target tissues like the hindbrain in supra-physiological concentrations