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(2) Clinical design deficiencies: most human trials utilize berberine chloride formulations not optimized for obesity-specific indications, coupled with inadequate endpoint selection targeting adiposity pathophysiology

Children under age 18 must have at least one weight-related health condition and their BMI must be in the 95th percentile for their age and sex based on current Centers for Disease Control and Prevention (CDC) charts

Intriguingly, this pro-adipogenic effect of GLP-1 is accompanied by decreased body weight in liraglutide-treated mice, in keeping with the well-described effect of liraglutide [75]

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Women planning to conceive are typically advised to discontinue at least two months before pregnancy