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Other than Trulicity, there are two other once-weekly GLP-1 agonists currently available: AstraZenecas Bydureon (exenatide) and GlaxoSmithKlines Tanzeum/Eperzan (albiglutide)

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April 2025, Northstrive Biosciences In semaglutide to reduce the risk of serious heart problems in obese or overweight adults, and semaglutide becomes the first we igh58 t loss drug approved in the UK as a preventative treatment for those with established cardiovascular disease

Unlike GnRH agonists that create an artificial menopause to suppress estrogen, the weight-mediated estrogen reduction through GLP-1 agonists is more physiological