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In human islets, GLP-1 promotes increased connectivity between individual cells to improve calcium kinetics and insulin secretion throughout the islets, and promotes insulin secretion from islet cells when cells detect both elevated blood glucose levels and hormonal signals from the intestine

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GLP-1 receptor agonists like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) begin affecting appetite and blood sugar within days to weeks, but clinically meaningful outcomes develop more gradually