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13 Two meta-analyses of other GLP-1 RA CVOTs found that GLP-1 RAs were associated with greater rates of DR progression, but both studies found that the effect was driven by the extent of hemoglobin A1c reduction, rather than the medications themselves

(4) GLP-1 travels through the bloodstream and binds to GLP-1 receptors on the pancreas, which causes pancreas to produce insulin

The concern is that combined central nervous system depression can lead to excessive drowsiness, confusion, impaired coordination, and in serious cases, slowed breathing

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