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Description

Longitudinal data were analyzed by two-way ANOVA followed by Tukey post hoc analysis ( db / db glucose and DIO mouse data) or two-way ANOVA followed by Sidak or Bonferroni post hoc analysis (HFHF canine acute oral glucose tolerance test data and 14-day data)

Sitagliptin, a amino acid derivative, has a terminal halflife between 10 and 12 h [98, 99], but its biological effect extends well beyond this time frame, similar to saxagliptin and vildagliptin

Rare but severe complications include pancreatitis and gallbladder problems

A major real-world study links GLP-1 receptor agonists to improved survival and lower recurrence risk in women with breast cancer, but researchers say clinical trials are needed before these drugs can be considered part of cancer care