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This strategy is based on an in-depth understanding of the distinct mechanisms of action of the two incretin hormones, GIP and GLP-1, in regulating body weight, glycemic control, and fat storage

This review delves into the pathogenesis of diabetes mellitus and CKD, highlighting the unique challenges these complications present in liver transplant recipients

NICE guidance (NG28) recommends considering GLP-1 receptor agonists for adults with type 2 diabetes when glycaemic targets are not achieved with other therapies, particularly in those with established cardiovascular disease or at high cardiovascular risk

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A dedicated Phase 3 trial evaluating retatrutide specifically for metabolic dysfunction-associated steatotic liver disease is currently underway