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Individual tolerance varies considerably, and many patients successfully continue treatment with minimal or manageable symptoms, particularly when appropriate dose escalation and dietary modifications are implemented

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Results Here, we show that among 25,060 matched pairs comparing Tirzepatide with Semaglutide, no differences emerge across ocular outcomes

Our findings support a model for long-acting GIPR agonists to modulate both fasted and fed adipose tissue function differentially by cooperating with insulin to augment glucose and lipid clearance in the fed state while enhancing lipid release when insulin levels are reduced in the fasted state