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Description
Farr et al
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Some of the reasons might be the known adverse effects of GLP-1, which are mainly gastrointestinal, and the injectable route of administration of GLP-1RA prescribed at the time of the study [8]
In primary human hepatocytes, GLP-1 RAs reduced lipogenesis by approximately 24.6% compared to untreated controls
Patients needed to inject it twice daily
Along with truncating the C-terminal, this exposes exenatide to NEP 24.11 degradation
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