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Desensitization and Receptor Trafficking Most agonist-activated GPCRs undergo rapid desensitization through a coordinated two-step process: first, phosphorylation of the receptor by GRKs, and second, recruitment of -arrestins to these phosphorylated sites, which sterically block further G-protein coupling [54]

Novel antipsychotics: comparison of weight gain liabilities

FEBS Lett (1987) 211(2):16974

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J Clin Endocrinol Metab 2018