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GLP-1 agonists affect diverse obesity etiopathogenic processes such as abnormal food intake regulation, adipocyte dysfunction, insulin resistance, adipokine production, inflammation, endothelial dysfunction, lipid metabolism, and oxidative stress

However, research suggests that tirzepatide may lead to greater average weight reduction, as shown in a major tirzepatide weight loss clinical trial

Pharmacol Biochem Behav (1988) 31(1):816

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Impacts of glucagon-like peptide-1 receptor agonists on the risk of adverse liver outcomes in patients with metabolic dysfunction-associated steatotic liver disease cirrhosis and type 2 diabetes

Osteoporos Int (2007) 18(4):42744.10.1007/s00198-006-0253-4 2 SeinoYKanekoSFukudaSOsonoiTShiraiwaTNishijimaKet alCombination therapy with liraglutide and insulin in Japanese patients with type 2 diabetes: a 36-week, randomized, double-blind, parallel-group trial