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GLP-1 agonism: Emerging hypotheses and limitations While GLP-1 RAs hold therapeutic promise for increasing lifespan and reducing the morbidity of age-related illness through action on multiple organ systems, tissue-specific effects of GLP-1R agonism are possible

JPD [Internet]

However, for patients with very high blood sugar at diagnosis (HbA1c above 10 percent) or symptoms of hyperglycemia, insulin may be started right away, bypassing the usual stepwise approach

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To counter such impacts, some companies are exploring ways that GLP-1RA drugs could complement their existing solutions

doi: 10.1001/jama.2016.10260