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One reason adverse events for compounded GLP-1 drugs are probably underreported is that people who prescribe or sell these drugs dont hear from patients when there are problems, Dushay says

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For example, FTO variants are associated with increased appetite drive, while GIPR and GLP1R variants influence how effectively GLP-1 agonists suppress hunger signals in your individual physiology

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Some patients take 23 month breaks after reaching a goal, then restart if weight returns

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