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People with underlying metabolic conditions, thyroid disorders, or hormonal imbalances may need targeted medical treatment rather than general supplement support
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The case series in Medicine specifically highlighted this mechanism, noting that the body water loss associated with GLP-1 agonists may be more significant than commonly appreciated

Until prices drop or value improves, broader public coverage remains a tough sell

N Engl J Med 2016;375:31122.PubMedPMC References Fig
