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Treatment targets and drug choices should be individualised according to patient needs, aligned with NICE guidance and local formularies

These predispositions indicate relative pathway sensitivity but do not predict exact medication response

The clinical investigators specifically noted that "gastrointestinal adverse events were partially mitigated by the use of a lower starting dose." Starting at 1 mg, which is what the Phase 3 TRIUMPH trials use, provides even more tolerability protection

For a broader overview of gastrointestinal and cardiac effects, see our referenced discussion in Side Effects of Wegovy to understand how multiple systems interact

This newly charted pathway - separate from previously described mechanisms that broadly affect appetite - could be an avenue by which GLP-1s treat other dysfunctions in reward processing, such as substance use disorder

It is not intended for human or veterinary use.