semaglutide not losing weight in and feeling frustrated? It’s probably NOT willpower. , The 3 biggest reasons I see in my patients: , 1. Under- eating , 2. Lack of movement/exercise, 3. Poor sleep, Why Am I Not Losing
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Why aren't there more?" ama-assn.org Last updated: January 5, 2026 Fact-checked with deep research Reviewed monthly as pricing and availability change Disclaimer The information on this page is for educational and informational purposes only and is not intended as medical advice

They are often prescribed to patients with obesity and/or Type 2 diabetes

In some clinical contexts, physicians may discuss Retatrutide with patients who require more intensive metabolic support, while Semaglutide may be considered when a more established therapeutic pathway is appropriate

It can help in achieving better blood sugar control and reducing the need for other diabetes medications

It is important to allow adequate time at each dose level before concluding that appetite suppression is insufficient

\Safety Profile: Mild-to-moderate GI side effects, usually resolving with dose titration
