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Its difficult to distinguish direct anti-inflammatory effects from the benefits of weight loss and improved metabolic health, but the pattern is consistent enough to warrant further study. A 2025 study found that RA patients with a BMI over 27 taking GLP-1 medications showed improvements in symptoms and disease activity

Diabetes patients

After 30 weeks, exenatide once weekly reduced A1C significantly more compared with the twice daily formulation (1.9% versus 1.5%

In the two approved albumin fusions, GLP-1 and FIX are fused to the N-terminal end of albumin due to functional requirements of the biologics 66,67,88,89,90,91

Funding Not applicable

Clinical studies back this up, showing steady pharmacokinetic profiles with GLP-1 therapies