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glucagon-like peptide-1 receptor agonists (GLP-1 RAs)

Type 2 diabetes mellitus (T2DM) is a major risk factor for cardiovascular disease

Recent Findings Newer generation GLP-1 based therapies have become more effective for the treatment of overweight and obesity, with data supporting tirzepatide as the most effective, followed by semaglutide and then liraglutide

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These effects were partially attenuated by GLP-1R small interfering RNA treatment

Compared with placebo (7.8%), relative muscle strength (strength normalized to body weight) was higher with exercise (0.4%), liraglutide (+1.0%), and the combined treatment (+3.3%) because of lower weight and preserved absolute strength