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However, while these results are compelling, the authors emphasize that this is a single-subject observation and underscore the need for large-scale randomized clinical trials to validate semaglutide and similar GLP-1 RAs as primary AUD treatments

As the wheel turns, it clicks

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These findings suggest that disruption of the leptin-proopiomelanocortin-MC4R circuit is associated with reduced executive control over eating behavior (126)

00:04:25 Vickie Danaher And it also reduces appetite by acting on receptors in the brain involved in hunger and satiety

In addition, if the manufacturers of the branded compounds are having difficulty obtaining enough of the actual medication it is unlikely that the compounders are able to obtain the actual medication