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doi: 10.1016/j.tifs.2021.04.009 17

A P-value of less than 0.01 was deemed statistically significant

Li X, Wu Q, Gao H, Cheng J, Chen H, Duan J, et al

CGA exhibits a good safety profile, which has not shown any obvious adverse effect and toxicity to normal cells or tissues, and is well-tolerated by humans [13,14]

Feelders RA, de Bruin C, Pereira AM, Romijn JA, Netea-Maier RT, Hermus AR, Zelissen PM, van Heerebeek R, de Jong FH, van der Lely AJ, de Herder WW, Hofland LJ, Lamberts SW

In HFD-induced NAFLD rats, the hepatoprotective effect of Jiaogulan (Gynostemma pentaphyllum (Thunb.) Makino) has been correlated with specific modulations of the gut microbiota (e.g., a reduced Firmicutes/Bacteroidetes ratio, increased Lactococcus, decreased Ruminococcus) and the preservation of intestinal barrier integrity, pointing to microbiota-mediated pathways as a likely component of its action [133]