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Congratulations to Eli Lilly and the broader obesity treatment community

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GLP-1 receptor agonists improve MASH mostly via extrahepatic actions: 1 CNS appetite control weight loss systemic inflammation 2 Chylomicron synthesis & improve lipid metabolism 3 Bind gut immune cells anti-inflammatory + microbiome benefits 4 Reduce adipose & pancreatic inflammation

Considering the central role of glucose catabolism for stimulus-secretion coupling in -cells, our findings suggest that chronic GLP-1 actions on insulin secretion include elevated -cell glucose metabolism