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We observed a trend toward inadequate bowel preparation in patients undergoing colonoscopy who were on [GLP-1s], which raised concerns about practical consequences to these medication side effects, lead author Rebecca Yao, MD, MPH, an internal medicine resident at Mayo Clinic, in Rochester, Minn., told Gastroenterology & Endoscopy News

Furthermore, since the instability of Ala 2 is caused by degradation of DPP-4, Ala 2 may not need to be changed if the peptide is fused with albumin or Fc domain (discussed later) for long-term activity, which creates a steric hindrance to prevent the enzyme from getting close

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2012;14(Suppl

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