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Key mechanisms include: Enhanced Glucose-Dependent Insulin Secretion: GLP-1 receptor stimulation amplifies insulin release only in the presence of glucose, minimizing hypoglycemia risk

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Raz I., Hanefeld M., Xu L., et al., Efficacy and Safety of the Dipeptidyl Peptidase4 Inhibitor Sitagliptin as Monotherapy in Patients With Type 2 Diabetes Mellitus, Diabetologia 49 (2006): 25642571

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