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These benefits were subsequently confirmed in well-powered studies specifically designed to evaluate kidney outcomes [1, 2]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 57.Zinman B, Bhosekar V, Busch R, Holst I, Ludvik B, Thielke D, Thrasher J, Woo V, Philis-Tsimikas A

We found that the maternal blood GLP-1 concentration decreased progressively during pregnancy, contrary to the increase in pancreatic islet GLP-1 content (15, 19)

Based on the intention-to-treat analysis, GLP-1RA therapy was linked to a consistently higher risk of the composite herpes outcome than DPP-4i (adjusted HR = 1.06, 95% CI 1.011.11), whereas no excess risk was seen when GLP-1RA was compared with SGLT-2i (Additional file 1: Table S14)

Kidney function - Severe gastrointestinal symptoms (vomiting, diarrhea) can lead to dehydration, which may affect kidney function