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PMCID: PMC2480499

Not ideal for long protocols

Potential for metabolic overstimulation: Chronic AMPK activation beyond physiological norms could theoretically disrupt normal energy signaling

High-fat foods sit in your stomach longer, increasing the likelihood of uncomfortable symptoms

Tirzepatide is a dual agonist that activates GLP-1 and GIP receptors to reduce appetite and regulate blood sugar

Although the pharmacological effects of the GLP1 receptor agonist, exendin4, to reduce food intake was also similar between knockdown and control mice (Table 3) (Burmeister et al., 2017), antagonism of GLP1 receptors in the arcuate nucleus inhibits the weight reducing effects of liraglutide (Secher et al., 2014)