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Description
GLP-1RAs mimic GLP-1 and have primarily been used for glycemic control in type 2 diabetes and for weight reduction in obese patients (8,9)

If results were minimal, redirect resources to approaches with better evidence

Semaglutide typically delivers faster and more substantial weight loss

95% CI, 0.44-0.84

Augmented GLP-1 secretion as seen after gastric bypass may be obtained by delaying carbohydrate digestion

Yet, this risk must be balanced against a largely neutral safety profile in broad observational studies and a potential for long-term benefit
