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The participants were split into two groups

Microdosing GLP-1s means taking a dose that is even lower than the lowest FDA-approved dose for a particular weight-loss medication, says Dr

In the second trial, SURPASS-2, tirzepatide administered at doses of 5 mg, 10 mg, or 15 mg showed superior efficacy compared to semaglutide (1 mg) in reducing body weight and HbA1c levels over 40 weeks in patients with T2DM inadequately controlled with metformin [66]

Retatrutide got the average trial patient well below that number

Unlike semaglutide, which targets only the GLP-1 receptor, tirzepatide is a dual-action medication that activates both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors

2025: Topline data from TRIUMPH-4 shows record-breaking weight loss of nearly 29%