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Finally, we demonstrate that in mice, both the efficacy and tolerability of GLP1R agonists vary with the phase of the estrous cycle, being highest during proestrus (when estrogen levels peak) and lowest in diestrus (low estrogen levels)

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Metabolic tracing of the isolated intestinal crypts further suggested that fructolysis activity is coupled to the ATP/ADP ratio in the L-cell-resident niche

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