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Dose optimization strategies Some patients and providers have found that lower doses, while producing less dramatic weight loss, are sufficient for weight maintenance

What raises concerns are some of the recent reports of serious ADRs associated with GLP-1RAs: (i) Pfizers disclosure of elevated aminotransferases in users of lotiglipron (a novel oral GLP-1RA) is indicative of hepatocellular injury [11]

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As Comorbidities Rise, GLP-1s Gain Ground Beyond Diabetes and Obesity Among the many conditions that frequently overlap with T2D and obesity, obstructive sleep apnea (OSA), MASHa subset of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), hypertension, and high cholesterol are among the most prevalent

doi: 10.1126/science.aat9351

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