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Fatigue followed a similar dose-dependent pattern, ranging from near 0% at the lowest dose to about 46% in some higher-dose arms, compared with about 13% in the semaglutide arm of STEP 3

Chandrasekhar K et al

This supports weight loss, but if you are not eating enough protein and your activity drops, you can lose lean body mass, or muscle, along with fat during rapid weight loss

ASA Guidance on Preoperative Management of GLP-1-RA Use In June 2023, the ASA released guidance on withholding GLP-1-RA to reduce aspiration risk based on anecdotal reports

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Glucagon-Like Peptide-1 Receptor Agonist Ameliorates 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Neurotoxicity Through Enhancing Mitophagy Flux and Reducing -Synuclein and Oxidative Stress