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The authors correlate the suppression of glucagon secretion with the observed effect (Oda et al., 2013)

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15% with semaglutide in clinical trials

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a 23 week flat period without any downward trend suggests metabolic adaptation

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Aim for 100-150g daily protein to [preserve lean mass during weight loss](/guides/glp1-muscle-loss-prevention-semaglutide-tirzepatide-guide) 6

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These figures come from separate trials in different populations and are not a direct head-to-head comparison

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