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Key Takeaways: Most patients lose 1225+ pounds in the first 3 months on tirzepatide once an effective dose is reached

The appetite suppression that felt dramatic at week four becomes barely noticeable by month eight

But read the fine print first

Sleep protection: Poor sleep can make appetite feel louder and decision-making harder

For most people, that difference is smalland for those who would not otherwise use an injectable medication, a pill may be the more practical choice

Despite the limitations, these data suggest that long term therapy is not associated with durable weight loss with withdrawal of the medication and supports guidelines for extended therapy