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Despite lots of big lingering questions, many clinicians dont think it actually matters right now how GLP-1 interacts with brain receptors on a cellular level, says Laura Huckins, PhD, an associate professor of psychiatry at the Yale School of Medicine

By week 26, patients on oral semaglutide experienced a significant drop in their HbA1c (a measure of blood sugar levels) by 1.3% versus a 0.9% reduction in those on empagliflozin

This is not because people lack discipline, but rather because their biology fights hard to return to its old set point

I was able to achieve my goal without undergoing risky surgical procedures

Understanding how long GLP-1 approaches take to start working helps set realistic expectations for any method you choose