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Clinical trials with GLP-1 receptor agonists consistently demonstrate significant weight loss, with higher doses (such as semaglutide 2.4 mg weekly) producing approximately 15% average weight loss in adults without diabetes in clinical trials (somewhat less in type 2 diabetes) when combined with lifestyle modification

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As recently as a few years ago the main options to support major weight loss were somewhat limited: physician-supervised nutritional interventions

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The encouraging news is that these symptoms are typically temporary and can be managed with a few simple lifestyle adjustments

Liraglutide | Drugs BNF (NICE)