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Cureus, 2021

4.2 GLP-1RAs and Other Types of Cardiomyopathy 4.2.1 Non-Diabetic Cardiomyopathy (NDC) In recent years, several pivotal clinical trials have provided important evidence supporting the use of GLP-1RAs in NDC

Tirzepatide had finished its last Phase 3 clinical trial SURPASS-5 in February 2022, 50 and it favors activating GIPR (for GIPR, native GIP EC 50 : 0.0334nM, tirzepatide EC 50 : 0.0224nM

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Patients often experience enhanced tolerability through the gradual therapeutic introduction, with a notably reduced incidence of gastrointestinal side effects

Novel Therapeutics in Diabetic Gastroparesis An effective, safe prokinetic is the goal for patients with gastroparesis, and medications in development, including ghrelin agonists and new generation 5-HT4 agonists, hold promise