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128 Our previous data showed that central IR may significantly affect the expression of synaptic plasticity proteins, such as postsynaptic density protein-95 (PSD95), Arc, synapsin1, BDNF, resulting in the impaired synaptic plasticity of neurons and decreased learning and memory ability (data not shown)

This finding is not unique to mice, as a similar response has been reported in musk shrews treated with direct injections of exenatide with and without exendin-9 into the AP and NTS (86)

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The homogenates were then centrifuged at 15,000 g for 20 min at 4 C to eliminate remaining waste