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Dapagliflozin once daily plus exenatide once weekly in obese adults without diabetes: sustained reductions in body weight, glycaemia and blood pressure over 1 year

Gastroenterology 85 , 11201130 (1983)

Caviness Distinguished Professor of Medicine at the University of North Carolina School of Medicine

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Leptin and gene therapy Leptin has been recognized as one of the therapeutic candidates for obesity and as a regulator of fat mass, but its therapeutic effect is limited because of the apparent development of leptin resistance and the decreased BBB transport that is, observed in obese subjects with elevated blood leptin levels

Most prescribers rely on individual risk-benefit assessment and documented treatment failure with conventional methods before offering GLP-1 therapy to minors