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Metformin, a common diabetes medication, has a half-life of about 4 to 6 hours

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10.1080/13543776.2016.1192130 [DOI] [PubMed] [Google Scholar] 33.Edwards CM, Stanley SA, Davis R, Brynes AE, Frost GS, Seal LJ, et al

Supplementary Table 3 indicates the meta-regressions

This analysis used wholesale acquisition costs, which may not represent actual health care payer costs, although an attempt to reflect the real-world cost was made in our sensitivity analysis described under the Methods section
Nonetheless, gastrointestinal adverse symptoms (e.g., nausea, vomiting) persist often, and long-term safety data are still being examined
