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Semaglutide for Weight Loss Presently, semaglutide is FDA-approved for weight loss under the brand name Wegovy
Taken together, these data suggest semaglutide lowers circulating lipotoxic factors (e.g., leptin, inflammatory mediators) and upregulates beneficial adipokines
The pharmacokinetics of semaglutide were evaluated following a single dose of 0.5 mg semaglutide in a study of patients with different degrees of hepatic impairment (mild, moderate, severe) compared with subjects with normal hepatic function
Other important safety considerations include hypoglycemia risk when combined with insulin or sulfonylureas, suicidal ideation (monitor for mood changes), and contraindication during pregnancy
