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Notably, the combination intervention was found to achieve 55% glycated hemoglobin near-normalization, making it a viable and preferable alternative to conventional dapagliflozin therapy in T2D remission

It was demonstrated that exenatide, a GLP-1R agonist, via activating the spinal dorsal horn GLP-1Rs, effectively blocked pain hypersensitivity and induced beta-endorphin release with subsequent activation of opioid receptors producing antinociception in pain hypersensitivity states (Gong et al

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