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The first goal of these trials was to prove GLP-1 receptor agonists cardiovascular safety, and majority of CVOTs were designed as non-inferiority trials

Results Upregulation of GLP-1R in the TNC after chronic NTG injection To examine whether GLP-1R was expressed in the TNC, we performed immunofluorescence for GLP-1R using a specific antibody, and our images showed that GLP-1R was specifically expressed in the TNC in normal mice (Fig

2023;8(12):e170671

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J.BirdT.Ertekin-TanerN.LincolnS.HjorthR.WuY.et al

These trials were specifically monitored for cancer-related adverse effects and found no notable differences in thyroid cancer incidence between the treatment and control groups