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Consequently, GLP-1 that is secreted by intestinal L-cells is rapidly degraded by dipeptylpeptidase-4 (DPP-4) in the endothelium of the portal circulation and in the liver, as well as by a soluble circulating moiety of DPP-4

Though GLP-1R receptor agonistdrugs work well on their own, they may work better when paired with the right lifestyle changes.

GLP-1s are becoming a bigger part of weight management

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### Competing Interest Statement TR, IG, TK, YW, DT are employees of Olio Labs Incorporated