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These often improve with slow dose increases

Table 1 organizes recent studies investigating the use of GLP analogs and DPP-IV inhibitors in IBD by study design, treatment arm, key results, and evidence classification with risk-of-bias assessment

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Clinicians should consider the use of semaglutide cautiously in patients with underlying NASH cirrhosis and should strictly adhere to the prescribing information and dose escalation protocols as recommended and consider using a lower dose of the drug