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Similar to the natural GLP-1 peptide, GLP-1R agonists such as exendin-4 have likewise been shown in animal models and humans to require glucose concentrations above basal levels to promote insulin secretion

It was cleaner

A 14 mg semaglutide pill form was associated with more weight loss than the injectable GLP-1s lixisenatide (which is no longer on the market in the United States) and exenatide

Thats a genuinely new frame, and it raises ethical questions weve barely started

Clinicians and patients should interpret early reports with appropriate caution and recognize the distinction between hypothesis-generating observations and proven therapeutic interventions
