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And unlike existing addiction medications, which are prescribed by specialists and remain vastly underused, GLP-1 drugs are already prescribed at enormous scale by primary care doctors

4.764.632 -1GLP-1RA--2SGLT-2i2GLP-1RA GLP-1RA2023 200 Chun-Su Yuan BMJComparative effectiveness of GLP-1 receptor agonists on glycemic control, body weight, and lipid profile for type 2 diabetes: systematic review and network meta-analysis 15 GLP-1 2 15GLP-1RAHbA1c Tirzepatide HbA1cTirzepatideGLP-1GIP CagriSema 2CagriSemaSemaglutideCagrilintideGLP-1RA GLP-1RAGLP-1RAGLP-1RAHbA1c GLP-1RA2FDAGLP-1RA2 exenatide liraglutide dulaglutide albiglutide lixisenatide semaglutide tirzepatide GLP-1RAGLP-1RAGLP-1RAMetaGLP-1RAGLP-1RA Orforglipron GLP-1 Retatrutide GLP-1 CagriSema +) GLP-1RA2GLP-1RAMeta 16316483763924658291878127856.7954.06%8.47BMI31.738.13%65 mmol/mol 16GLP-1RATaspoglutide15GLP-1RA873 15GLP-1RA HbA1c15GLP-1RA2HbA1c Tirzepatide2.10% Mazdutide2.09% CagriSema 1.80% 15GLP-1RAHbA1c 15GLP-1RA Tirzepatide3.12 mmol/L CagriSema Orforglipron 15GLP-1RA CagriSema 14.03GLP-1RATirzepatideRetatrutideOrforglipronSemaglutideLiraglutide 15GLP-1RA MetaGLP-1RA LixisenatideSemaglutideExenatideTirzepatideLiraglutide CagriSemaTirzepatideRetatrutideOrforglipronSemaglutideEfpeglenatideDulaglutideLiraglutidExenatid AlbiglutidePEG-loxenatideMazdutide12GLP-1R 10GLP-1RA ITCA 650CagriSemaOrforglipronEfpeglenatideTirzepatideLixisenatideSemaglutideLiraglutideExenatideDulaglutide 15GLP-1RA Meta15GLP-1R2OrforglipronRetatrutideCagriSema15GLP-1RAHbA1c Tirzepatide HbA1cTirzepatideGLP-1GIP CagriSema 2CagriSemaSemaglutideCagrilintideGLP-1RA |

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While dual and triple agonists represent a promising area of pharmacologic innovation, their role in adolescent obesity management cannot be established without dedicated pediatric clinical trials

10.1038/s41598-021-81349-7 131 YasudaN.InoueT.NagakuraT.YamazakiK.KiraK.SaekiT.et al (2002)

Another study focusing on liraglutide users reported that 85.6% of participants lost more than 4.4 lbs (2 kg) within 50 days, with an average loss of 10.8 lbs (4.9 kg)